RNA Details
Disease Name
cystic fibrosis
Tissue
pancreas
RNA Symbol
Bcl2
RNA ID
RNA Type
mRNA
Alteration Pattern
down regulation
Species
rattus norvegicus
Detection Methods
RT-PCR etc.
Target
NA
Pathway
NA
PubMed ID
Title
Angiotensin II mediates acinar cell apoptosis during the development of rat pancreatic fibrosis by AT1R
Year
2004
Function
"Losartan prevents apoptosis of pancreatic acinar cell by blocking at1r during the development of pancreatic fibrosis. This action may be associated with its regulation of apoptosis-associated genes, such as bax, bak, and bcl-2 mrna. The results of present study suggest that angiotensin ii probably mediates pancreatic acinar cell apoptosis during the course of pancreatic fibrosis."